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Adriano Aguzzi has devoted his professional life to deciphering the role of the immune system in prion diseases. His current research projects include the application of powerful robotic platforms for the genome-wide identification of factors controlling prion replication and susceptibility to prion infection. Using massively arrayed CRISPR lentiviral libraries for high-throughput screens as the tool of choice Aguzzi aims to interrogate the consequences of genome perturbations in disease pathogenesis. Aguzzi stands out as a pioneer who has tackled one of the most demanding tasks in neurobiology and elucidated the immunological and molecular basis of prion pathogenesis.
Jiang-An Yin’s research focuses on neurodegeneration and aging, with a particular emphasis on addressing critical, challenging, and underexplored areas in these fields through innovative and integrative methodological approaches. He has made a groundbreaking contribution to aging research by demonstrating that lifespan extension can be uncoupled from healthspan, shifting the paradigm toward healthy aging research. His research dissects the genetic basis of natural variation in aging rates and identifies a novel neuropeptide-mediated glia-neuron signaling pathway regulates healthy aging. In recent years, Jiang-An has expanded his research into neurodegeneration, aiming to uncover novel gene modifiers of Parkinson’s disease and prion diseases. He has developed high-efficiency arrayed CRISPR libraries for the activation, ablation, and epigenetic silencing of human protein-coding genes. This globally unique and powerful tool has greatly expanded the phenotypic territory of CRISPR-based screening and is transforming the study of neurodegenerative diseases and advancing broader biomedical research.
Artemi Bendandi has a PhD in Physics from the University of Genoa, Italy. After obtaining her Masters degree in Physics with a thesis in Theoretical Particle Physics in the University Roma Tre in Rome, Italy, she moved to Genoa, Italy to conduct research on the electrostatic interactions of proteins and nucleic acids in the Italian Institute of Technology. She came to Zurich as a postdoctoral researcher in the University of Zurich before becoming a Grant Manager & Scientific Coordinator in the Institute of Neuropathology in 2022.
