Our paper describing our CRISPR libraries and cloning method has been published in Open Access!
Yin, JA., Frick, L., Scheidmann, M.C. et al. Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes. Nat. Biomed. Eng 9, 127–148 (2025).https://doi.org/10.1038/s41551-024-01278-4
Our libraries have been used in the following works:
- Ging, K., Frick, L., Schlachetzki, J. et al. Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2. npj Parkinsons Dis. 10, 192 (2024). https://doi.org/10.1038/s41531-024-00819-7
- Company, C., Schmitt, M.J., Dramaretska, Y. et al. Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes. Nat Commun 15, 897 (2024). https://doi.org/10.1038/s41467-024-45069-6
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Sellitto, Stefano,
et al. Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex.
bioRxiv (2024): 2024-10.
https://doi.org/10.1101/2024.10.21.619371
